Program:

Friday, 07 March, 1997
Arrive in Banff. Check into room at Banff Springs Hotel.

7:00 p.m. Mount Stephen Hall
- Private Reception

Banquet to follow

Saturday, 08 March, 1997
7:00-8:00 a.m. Set up posters - Baron Shaughnessy Ballroom

8:00 am    Welcome, Opening Remarks,
                Description of Internet/CD Publishing Link, Introduction of Dr. Marovitz. .... Kim Solez

8:10        The Internet and Medical Publishing. . . . . William F.Marovitz, President and CEO, Churchill Livingstone International

8:40        Discussion

8:50        Transplant Pathology Internet Services (TPIS) resource and relation to Banff meeting (http://tpis.upmc.edu/) . . . . A.J. Demetris and Charles Richert

9:00        Discussion

9:05        Pathology image transmission over the Internet . . . . Yukako Yagi

9:20        Discussion

9:25        Plan of the Meeting from a Renal Perspective . . . . Lorraine C. Racusen

9:35        Plan of the Meeting from a Liver Perspective . . . . A. J. Demetris

9:45        Current Status of Heart Transplant Pathology (and Lessons There from!) TBA

9:50        Current Status of Lung Transplant Pathology . . . . Samuel A. Yousem

10:00     Coffee Break

10:20     The Banff Schema Six Years Later: Experience from International Clinical Trials of New Anti-rejection Agents . . . . . Kim Solez

10:40     Discussion

10:45     The 1995 Efficacy Endpoints Conference Group, The role of the Banff classification in clinical immunosuppression trials . . . . Lillian Gaber

11:00     Discussion

11:05     Early risk factors for allograft failure . . . . Peter Nickerson

11:25     Discussion

11:30     Significance of "subclinical rejection" with implications for therapy . . . . David Rush

11:55     Discussion

12:00     The UK-wide study of the Banff Schema and A Neural Network Approach . . . . Peter Furness

12:25     Discussion

12:30     Box Lunch in Poster Area - Baron Shaughnessy Ballroom

Afternoon Plenary Session - Conference Centre Theatre - Chair - Lorraine Racusen

2:00     Further studies of the clinical value of the Banff system for renal allograft pathology . . . . S. Olsen, H.E. Hansen, M. Madsen

2:15     Discussion

2:20     The CCTT scoring system . . . . Robert B. Colvin

2:35     Discussion

2:40     Significance of eosinophils and neutrophils in renal allografts . . . . John Papidimitriou

2:55     Discussion

3:00     HLA-DR and C4D: Useful diagnostic and prognostic markers in renal transplants? . . . . Michael Mihatsch

3:25     Discussion

3:30     Coffee Break

Basic Science Session - Molecular Mechanisms of Rejection Phil Halloran and Pekka Hayry, Chairs

3:50     Molecular mechanisms of acute rejection with therapeutic targets . . . . Phil Halloran

4:10     Immunopathogenesis of acute rejection . . . . Robert B. Colvin

4:30     Mechanisms of T-cell mediated killing: The Hole Story is not the Whole Story. . . . . Chris Bleakley

4:50     Discussion

5:00     Molecular mechanisms of chronic rejection with therapeutic targets . . . . Pekka Hayry

5:20     The analogy between chronic rejection and atherosclerosis . . . . Stephen M. Schwartz

5:40     Integrin adhesion molecules, vascular ligands and extracellular matrix in acute and chronic rejection . . . . Daniel Salomon

6:00     Discussion

6:15     Return to posters - Baron Shaughnessy Ballroom

7:30     Dinner

Sunday, 09 March, 1997
Conference Centre Theatre - Renal Presentations I - Larry Hunsicker - Chair

8:00 a.m. Scanning electron microscopy of tubular pole abnormalities in chronic rejection . . . . Ian Gibson

8:15     Discussion

8:20     Macrophages and thromboxane synthetase in acute rejection . . . . Byron Croker

8:35     Discussion

8:40     Reproducibility of chronic rejection scoring using the Banff schema . . . . Niels Marcussen

8:55     Discussion

9:00     Kidney Working Session - Kim Solez - Chair 

12:00   Lunch

1:30 p.m. Baron Shaughnessy Ballroom
- Liver Presentations and Working Session - Jake Demetris - Chair

R. Lee - Application of the Banff Schema for acute liver allograft rejection: how does it work in practice?

S. Hubscher - Current issues on Chronic liver allograft rejection

K. Batts - Impact of HCV infection on liver allograft histology and rejection: the NIDDK experience

7:00     Dinner

Monday, 10 March, 1997
8:00 a.m. Baron Shaughnessy Ballroom
- Liver Working Session - Jake Demetris - Chair

L. Petrovic - The problem of HCV infection overlapping with rejection

A.J. Demetris - Reliability of the histopathological diagnosis of chronic rejection: results of an inter-institutional study

J. Fung - Clinical aspects of chronic rejection, including overlap with HCV infection.

12:00     Lunch

1:00 p.m. Conference Centre Theatre
- Special minisymposium on PTLD - M. Nalesnik, M.D., Chair

1:00     Glauco Frizzera, M.D.: Pathology and pathogenesis of posttransplant lymphoproliferative disorders: a historical perspective.

1:30     Margaret L. Gulley, M.D.: Epstein-barr virus and posttransplant lymphoproliferative disease. Clinical and molecular aspects.

2:00     Steven H. Swerdlow, M.D.: Summary of Society of Hematopathology workshop on posttransplant lymphoproliferative disorders.

2:30     Daniel M. Knowles, M.D.: Molecular aspects of posttransplant lymphoproliferative disorders.

3:00     Break

3:15     Cinthia Drachenberg, M.D.: Early onset PTLD in recipients of kidney-pancreas grafts

3:45     Jorge Reyes, M.D.: Treatment approaches to posttranslant lymphoproliferative disease.

7:00 p.m. Baron Shaughnessy Ballroom
- PTLD Slide Review with box supper

Tuesday, 11 March, 1997
Conference Centre Theatre - Renal Presentation II - Dan Salomon - Chair

8:00 a.m. The Simulect trials in renal transplantation - TBA

8:20     Discussion

8:30     Renal biopsies in the military - The need for Banff-like scoring in native kidney biopsies - TBA

8:50     Discussion

9:00     Kidney Working Session - Kim Solez - Chair

12:00     Lunch

1:00 p.m. Baron Shaughnessy Ballroom
- Liver Working Session - Jake Demetris - Chair

8 p.m. Farewell Banquet

Wednesday, 12 March, 1997
8:00 a.m. Conference Centre Theatre
- Manuscript discussion - led by Drs. Solez, Racusen, Demetris, Halloran, and Nalesnik

Departure or skiing

(Thursday 13 March, Friday 14 March CCTAT meeting chaired by Larry Hunsicker)

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