Banff Working Groups (BWGs)
Six BWGs aiming at
addressing unmet needs in transplantation pathology were established at the 10th
Banff Conference on Allograft Pathology
(Figure 1). These
international BWGs will collect data on areas where Banff criteria are
problematic, work with multiple centers, validate the results, and ultimately
refine and improve the classification, thus ensuring that the Banff process is
evidence-based and continues to lead to improvements in patient care and
Transplant physicians from around the world are encouraged to participate in the BWGs.
Isolated v-lesion BWG:
Aim: To address the significance of isolated v- lesions (with little or no tubulo-interstitial inflammation) in renal allograft biopsies. At present, 144 biopsies with isolated v-lesions have been collected from 7 centers. Work will soon commence comparing outcomes of patients with isolated v-lesions with control groups.
To participate, please contact Banu Sis, MD, FRCPC, email@example.com
Fibrosis scoring BWG:
Aim: To standardize fibrosis scoring in renal native and allograft biopsies, and conduct multi-center reproducibility trials to improve interobserver agreement.
To participate, please contact Robert Colvin, MD, COLVIN@HELIX.MGH.HARVARD.EDU
Polyoma virus nephropathy staging BWG:
Aim: To ensure the reproducibility of the new polyoma virus nephropathy staging, which was approved by consensus with pending training trials.
To participate, please contact Volker Nickeleit, MD, firstname.lastname@example.org
Glomerular lesion scoring BWG:
Aim: To re-examine scoring glomerular double contours (cg), glomerulitis (g), and mesangial matrix increase (mm) aiming at refinement of these criteria to increase the interobserver reproducibility.
To participate, please contact Mark Haas, MD, PhD, email@example.com
Molecular Pathology BWG:
Aim: To combine graft biopsy findings and molecular parameters for diagnosis in the near-future. The group led by Phil Halloran will facilitate the consensus about how and which molecular markers can be integrated into the Banff classification. RT-PCR or chip (with few genes) based molecular measurements may be incorporated into the existing histology-based Banff classification and/or discovery of new diagnostic and/or prognostic tissue markers could be feasible with the help of omics technologies.
To participate, please contact Philip Halloran, MD, FRCPC, OC, firstname.lastname@example.org
Aim: To plan Banff training courses, proficiency tests, and immunohistochemistry (C4d and BK) multicentre staining trials.
To participate, please contact Michael Mengel, MD, email@example.com
Figure 1. Established Working Groups at the Banff 2009 meeting aiming at addressing current unmet needs within the Banff classification to support or refute potential changes to the classification via conducting multi-center trials.
(Sis B, Mengel
M, Haas M, Colvin RB, Halloran PF, Racusen LC, Solez K et al. Banff ’09 Meeting
Report: Antibody Mediated Graft Deterioration and Implementation of Banff
Working Groups. Submitted, 2009)
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Last Modified: October 12, 2012 11:04:44 AM