Banff 2009

Banff, Alberta, Canada
August 9-14, 2009
Rimrock Resort Hotel

10^th Banff Conference on Allograft Pathology

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SUNDAY 9 AUGUST 2009 (Registration)

Time	Topic	Location
	Arrival

1:00 - 4:00	Registration	Wildrose Prefunction Area

MONDAY 10 AUGUST 2009 (Day 1)

Time	Topic	Speaker
	Plenary Session: Antibody-mediated rejection in allografts	Michael Mengel, Banu Sis

8:00 - 8:30	Welcome and overview	Kim Solez, Lorraine Racusen
8:30 - 9:00	Historical review, pathology and animal models of ABMR	Bob Colvin
9:00 - 9:30	Anti-graft antibodies in transplantation – detection and monitoring	Andrea Zachary
9:30 - 10:00	Complement dependent and independent mechanisms of antibody mediated graft injury	Wink Baldwin

10:00 - 10:30	Coffee Break

10:30 - 11:00	Diagnosis of ABMR in lung transplants	William Wallace
11:00 - 11:30	Current treatment and clinical outcomes for ABMR: New therapy options and potential trials	Mark Stegall
11:30 - 12:00	Questing new therapies for ABMR: C5 blockade in presensitized recipients	Hao Wang
12:00 - 12:10	Accelerated renal arteriosclerosis post-transplant	Gary Hill

12:10 - 1:00	Lunch

	Session: Updates from the 2007 Banff Conference	Kim Solez, Mark Haas
1:00 - 1:30	Plenary Address - Advances in histocompatibility -Report from the 15th International Histocompatibility and Immunogenetics Workshop	Maria Gerbase de Lima
1:30 - 1:45	Significance of focal C4d deposition	Helen Liapis
1:45 - 2:00	Significance of focal C4d deposits in the kidney	Parmjeet Randhawa
2:00 - 2:30	Significance of the total i-score	Michael Mengel
2:30 - 2:45	Significance of isolated v lesions: Clinical and molecular features	Edward Kraus
2:45 - 3:00	Molecular associations of isolated v lesions	Banu Sis

3:00 - 3:30	Coffee Break

3:30 - 4:00	Significance of alternative arteriolar hyalinosis (aah) scoring	Verena Broecker
4:00 - 4:30	Significance of zero-time biopsies	Christophe Legendre
4:30 - 5:00	Proposal for a BK-nephropathy Banff consensus classification	Volker Nickeleit

5:00 - 5:15	Discussion

7:00 - 11:00	Gala Dinner Evening

TUESDAY 11 AUGUST 2009 (Day 2)

Time	Topic	Speaker
	Plenary Session: Endothelial cells in transplantation	Lorraine Racusen, Wink Baldwin

8:00 - 8:30	Anti-HLA antibody induced autoimmunity: role in chronic rejection	Thalachallour Mohanakumar
8:30 - 9:00	A new type of antibody-mediated rejection defined by endothelial transcripts	Banu Sis
9:00 - 9:30	Endothelium and platelets in rejection	Wink Baldwin
9:30 - 10:00	Effector functions of antibody FC fragment in endothelial cell injury	Barbara Wasowska

10:00 - 10:30	Coffee Break

10:30 - 11:00	Endothelium and transplant arteriosclerosis	Beatrice Charreau
11:00 - 11:30	The specialized structure and function of kidney endothelium	Barbara Ballermann
11:30 - 12:00	Endothelial engineering and (xeno)grafting	Peter Cowan

12:00 - 1:00	Working Lunch - Consensus discussion for grading BK-Nephropathy	*Volker Nickeleit*

	Concurrent Session: Kidney: C4d and Antibody-mediated rejection in kidney transplants	Bob Colvin, Heinz Regele
	Concurrent Session: Liver	Jake Demetris, Stefan Huebscher
1:00 - 1:15	Kidney: Relationship of transplant glomerulopathy to C4d and alloantibodies	Banu Sis
1:15 - 1:30	Kidney: Significance of C4d staining with minimal histological abnormalities	Mark Haas
1:00 - 1:30	Liver: Introduction, challenges and focus of the sessions and meeting	Anthony Demetris
1:30 - 1:45	Liver: Discussion	Open to all participants
1:30 - 2:00	Kidney: Early detection of transplant glomerulopathy	Brian Nankivell
1:45 - 2:15	Liver: Immunologic aspects of HCV, autoimmunity and liver allograft acceptance	Geoff McCaughan
2:00 - 2:30	Kidney: C4d fixing antibodies: role in ABMR	Heinz Regele
2:15 - 2:30	Liver: Discussion	Open to all participants
2:30 - 3:00	Kidney: Predictors of outcome in ABMR	Denis Glotz
2:30 - 3:00	Liver: The spectrum of findings in protocol and indicated biopsies in long-term liver allograft recipients with an emphasis on diagnostic challenges	Stefan Hubscher

3:00 - 3:30	Coffee Break

3:30 - 4:00	Kidney: Does graft accommodation really occur? Mechanisms and long term outcomes	James Gloor
3:30 - 3:45	Liver: Discussion	Open to all participants
3:45 - 4:15	Liver: Biomarker prediction of successful weaning of liver allograft recipients	Alberto Sanchez Fueyo
4:00 - 4:30	Kidney: Analysis of renal transplant protocol biopsies in ABO-incompatible kidney transplantation	Kazunari Tanabe
4:15 - 4:30	Liver: Discussion	Open to all participants
4:30 - 5:00	Kidney: Diagnosis of AMR - controversies and implications from the clinicians (medical –surgical)' point of view	Millie Samaniego
4:30 - 5:00	Liver: Complete withdrawal of immunosuppression in liver transplantation	George Mazariegos

5:00 - 5:15	Discussion

7:00 - 9:00	Case presentations from various organs with Wine and Cheese

WEDNESDAY 12 AUGUST 2009 (Day 3)

Time	Topic	Speaker
	Plenary Session: Surrogate/Non-invasive markers in transplantation	Kim Solez, Gunilla Einecke
	Concurrent Morning Session: Heart: Antibody mediated rejection in heart transplantation	Rene Rodriguez, Adriana Zeevi

8:00 - 8:05	Heart: Introduction and goals for the session	Rene Rodriguez, Adriana Zeevi
8:05 - 8:30	Heart: Gene expression in AMR - The Edmonton data from 100 microarrays of heart allograft biopsies	Banu Sis
8:00 - 8:30	Plenary Session: Non-invasive prediction of acute rejection in renal allografts	Manikkam Suthanthiran
8:30 - 9:00	Plenary Session: Genomics and outcomes after renal transplantation	Rainer Oberbauer
8:30 - 8:50	Heart: Markers of Antibody Mediated Rejection and Accommodation in Heart Transplantation	Rene Rodriguez
8:50 - 9:30	Heart: Antibodies and the cardiac allograft: types, temporal appearance and minimum follow-up data points to assess a trend. How to interpret in conjunction with the clinical and pathology team	Adriana Zeevi, Nancy Reinsmoen
9:00 - 9:30	Plenary Session: Allo-specific cells as non-invasive markers of rejection risk and immunosuppressive effect	Rakesh Sindhi
9:30 - 10:00	Plenary Session: Urine proteomics in chronic allograft dysfunction	Josep Campistol
9:30 - 9:50	Heart: Diagnosis of AMR - controversies and implications from the clinicians (medical –surgical) point of view	Boudi Kfoury

10:00 - 10:30	Coffee Break

10:30 - 10:45	Heart: AMR Current Practice Survey - Europe	Margaret Burke, Annalisa Angelini
10:45 - 11:00	Heart: AMR Current Practice Survey - North America	Marc Halushka
10:30 - 11:00	Plenary Session: Non-invasive approaches to diagnosis in liver allografts	Hans Pratschke
11:00 - 11:15	Heart: AMR Experience from Birmingham, UK	Desley Neil
11:15 - 11:30	Heart: AMR Experience from Boston	Rex Neal Smith
11:00 - 11:30	Plenary Session: Erythrocyte C4d as a non-invasive marker of AMR	Thalachallour Mohanakumar
11:30 - 11:45	Heart: AMR Experience from Cleveland	Carmela Tan
11:30 - 12:00	Plenary Session: Omics Technologies for identification of immune tolerance	Robert Lechler
11:45 - 12:00	Heart: Summary of the presentations, and targeted questions to be addressed in the remainder of the heart session	Rene Rodriguez, Adriana Zeevi

12:00 - 1:00	Working Lunch - Revisiting the Banff criteria for scoring Transplant-Glomerulopathy	Mark Haas

	Concurrent Session: Heart: Antibody mediated rejection in heart transplantation	Rene Rodriguez, Adriana Zeevi
	Concurrent Session: Pancreas	Cinthia Drachenberg, Ed Kraus
	Concurrent Session: Composite Tissue	Linda Cendales
1:00 - 3:00	Heart: Patterns of C4d and C3d deposition in AMR - Reproducibility among centers. Presentation of reproducibility exercise of C4d and C3d staining of the same exact patients in European and North American Centers) (Immunohistochemical and Immunofluorescence)	Open to all participants
1:00 - 1:30	Pancreas: Gene expression based categorization of pancreas transplant biopsies	Fu Luan
1:00 - 1:30	Composite Tissue: Histological manifestations of skin rejection after treatment with Efalizumab in a bilateral arm transplant	Andreas Nerlich
1:30 - 2:00	Pancreas: Reproducibility of Banff schema for grading of acute pancreas rejection	Erika Bracamonte
1:30 - 2:00	Composite Tissue: Histological Manifestations of rejection in Mucosa	Jean Kanitakis
2:00 - 2:30	Pancreas: Antibody mediated allograft rejection: Leiden experience	Ingeborg Bajema
2:00 - 2:30	Composite Tissue: Antibody Mediated Manifestations in Peripheral Tissues	Wink Baldwin, Wilma Bergfeld
2:30 - 3:00	Pancreas: Antibody mediated allograft rejection: Wisconsin experience	Jose Torrealba
2:30 - 3:00	Composite Tissue: Short and Long term Histological Manifestations after Hand Transplantation	Carolyn Burns

3:00 - 3:30	Coffee Break

3:30 - 4:45	Heart: Discussion - Use and interpretation of Serologic Data (Correlation with allograft dysfunction and complement deposition)	Open to all participants
3:30 - 4:00	Pancreas: Antibody mediated allograft rejection: Sao Paulo (Brazil) experience	Erika Bevilaqua Rangel
3:30 - 4:00	Composite Tissue: Histological manifestations of the skin in the first face transplant in the United States	Wilma Bergfeld
4:00 - 4:30	Pancreas: Controversial lesions in pancreas biopsy grading	Lois Arend
4:00 - 4:30	Composite Tissue: Histologic features of cutaneous acute and chronic GVHD	Chyi-Chia Richard Lee
4:45 - 5:15	Heart: Summary of the session	Rene Rodriguez, Adriana Zeevi
4:30 - 5:00	Pancreas: Group discussion: Updates to the Banff classification	Open to all participants
4:30 - 5:00	Composite Tissue: Stress responses in composite tissue allograft skin	Brian Pollack

5:00 - 5:15	Discussion

7:00 - 9:00	Poster Presentations with Wine & Cheese

THURSDAY 13 AUGUST 2009 (Day 4)

Time	Topic	Speaker
	Plenary Session: The molecular phenotype of transplant biopsies - the way to diagnostic consensus	Phil Halloran, Gunilla Einecke

8:00 - 8:30	Report of transcriptome pre-meeting symposium	Phil Halloran
8:30 - 9:00	Approaching large data sets: class discovery, class comparison, class prediction, and validation strategies	Jeff Reeve
9:00 - 9:30	Molecular heterogeneity of T cell-mediated rejection in renal allograft biopsy	Konrad Famulski
9:30 - 10:00	Changes in the transcriptome during epithelial deterioration	Gunilla Einecke

10:00 - 10:30	Coffee Break

10:30 - 11:00	The molecular phenotype of heart allograft biopsies	Mario Deng
11:00 - 11:30	Correlating histopathology to microarray expression data in heart allograft biopsies	Michael Mengel
11:30 - 12:00	Panel discussion: Developing a consensus pathway for integration of omics-technologies into Banff	Open to all participants

12:00 - 1:00	Working Lunch - Revisiting the Banff criteria for scoring IFTA	*Bob Colvin*

	Concurrent Session: Liver	*Jake Demetris, Stefan Huebscher*
	Concurrent Session: Kidney: Phenotyping late allograft deterioration	Lorraine Racusen, Michael Mengel
1:00 - 1:30	Liver: Protocol biopsy findings in long-surviving liver allograft recipients: an emerging problem of “autoimmunity”	Mylene Sebagh
1:00 - 1:30	Kidney: Late kidney allograft loss: What we know about it, and what we can do about it	Roz Mannon
1:30 - 1:45	Liver: Discussion	Open to all participants
1:45 - 2:15	Liver: Immunosuppressive management decisions in long-term liver allograft recipients – relationship to biopsy findings	James Neuberger
1:30 - 2:00	Kidney: Etiology of late allograft loss: results from the DEKAF study	Arthur Matas
2:00 - 2:30	Kidney: Role of Calcineurin inhibitors for late allograft loss	Brian Nankivell
2:15 - 2:30	Liver: Discussion	Open to all participants
2:30 - 3:00	Liver: Weaning immunosuppression from long-surviving live donor liver allograft recipients with prospective biopsy monitoring: Preliminary results of the Immune Tolerance Network Pediatric experience	Sandy Feng
2:30 - 3:00	Kidney: Role of Recurrent disease for late allograft loss	Fernando Cosio

3:00 - 3:30	Coffee Break

3:30 -3:45	Liver: Discussion	Open to all participants
3:30 - 4:00	Kidney: Molecular associations of IFTA	Michael Mengel
3:45 - 4:15	Liver: Clinical, immunological, and pathological observations in tolerant liver allograft recipients	Takaai Koshiba
4:00 - 4:30	Kidney: Chronic glomerular lesions in serial biopsies	John Papadimitriou
4:15 - 5:00	Liver: Discussion	Open to all participants
4:30 - 5:00	Kidney: Interpretation of sequential protocol biopsies in terms of prognosis and clinical implications	Daniel Seron

5:00 - 5:15	Discussion

6:15 - 10:00	Banff Nature Tour with Gondola Ride	Pick up and Drop off at the Rimrock Lobby

FRIDAY 14 AUGUST 2009 (Day 5)

Time	Topic	Speaker
	Plenary Session: Summary of organ sessions	Mark Haas, Bob Colvin

7:30 - 8:00	Kidney	Lorraine Racusen
8:00 - 8:10	BKN consensus classification summary	Volker Nickeleit
8:10 - 8:40	Pancreas	Cinthia Drachenberg
8:40 - 9:10	Heart	Rene Rodriguez
9:10 - 9:40	Liver	Jake Demetris
9:40 - 10:10	Composite Tissue	Linda Cendales

10:00 - 10:30	Coffee Break

10:30 - 11:00	Omics Technologies	Phil Halloran
11:00 - 11:30	Virtual microscopy as a tool for QA in Transplantation Pathology: report of a Banff working group	Mark Haas, Banu Sis
11:30 - 12:00	*Key Note Lecture* - "The Banff classification for allograft pathology: where we started, where we are now, where we will go"	Phil Halloran

12:00 - 1:00	Lunch at Rimrock Resort Hotel

1:30	Bus departs for Banff Centre	Location: Meet in Rimrock Lobby
2:15 - 2:30	Tour of the first Banff Conference location

2:30 - 3:00	"Nutri-Break" Snack Break	Location: Max Bell Central Foyer

	Session: Telepathology	*Jake Demetris*

3:00 - 3:30	Digital pathology: problems, promises and application to transplantation	Jake Demetris
3:30 - 4:00	Medical-legal aspects of telepathology	Stanley Leung
4:00 - 4:30	The vision and workflow dynamics of Omnyx digital pathology solutions	Tony Melanson
4:30 - 5:00	New developments in digital pathology and Zeiss imaging solutions	Andrew Lesniak

5:00 -5:30	Coffee Break

5:30	Farewell Outdoor Barbecue Dinner